Liquid biopsy is a minimally invasive technology for detection of molecular biomarkers without the need for expensive or invasive procedures. It is a simple and non-invasive alternative to surgical biopsies which enables medical doctors to discover a range of information about a disease or a tumour through a simple blood sample. Unlike tissue biopsy where the tumor DNA is preserved in formalin-fixed paraffin embedded (FFPE) blocks, DNA cross linking does not occur with liquid biopsy; thereby facilitating tumor DNA sequencing. In June 2016, the FDA approved the first liquid biopsy test, the cobas EGFR Mutation Test, as a cfDNA test for the EGFR gene mutation in blood from lung cancer patients. Currently, there continues to be a growing interest in the liquid biopsy assay, including an increasing number of companies involved in the development of these tests for the diagnosis and stratification of cancer patients.
Liquid Biopsy Market Outlook
- The global liquid biopsy market is observing significant growth owing to advantages of liquid biopsy over solid tumor biopsy, rise in awareness about minimally invasive procedures, favorable government initiatives, and presence of huge cancer population base
- Easy and non-invasive access to the tumor genome, early cancer diagnosis & detection, characterization of new lesions, drug & therapeutic target identifications for cancer treatment are some advantages of liquid biopsies, which improve the safety and efficiency of cancer therapy
- However, low sensitivity and specificity of liquid biopsy is hampering the market growth
Liquid biopsy Market COVID-19 Impact
- The global pandemic of Coronavirus (COVID-19) has triggered stock market instability, tight border controls, and worldwide lockdown, leading the chemical industry, as well as large companies and governments, to restock supply chains
- The whole world is experiencing severe impact on social and financial sectors, and all global industries are facing challenges during the COVID-19 pandemic
- Rising support from governments and several companies can help in the fight against this highly contagious disease
- There are some industries that are struggling and some are thriving. Overall, almost every sector is anticipated to be impacted by the pandemic
Liquid Biopsy Market Segmental Highlights
- The report analyses the global liquid biopsy market based on products, circulating biomarker, sample type, application, end user and geography
- Based on products, the market is categorized into assay kits, instruments and services
- The liquid biopsy instruments automate the isolation of CTC cells. The instrument automates flow cell priming, blood sample loading, target cell isolation, and immunofluorescent labeling of captured cells on the flow chip.Various circulating biomarkers of the liquid biopsy market are Cell-Free DNA (cfDNA), Circulating Tumor Cells (CTCs), Circulating Tumor DNA (ctDNA), Extracellular Vesicles (EVs) and Other circulating biomarkers include circulating RNA (ctRNA and cfRNA) and cell-free protein biomarkers
- The liquid biopsy industry finds its major application for cancer (breast cancer, colorectal cancer, liver cancer, lung cancer, prostate cancer) and non-cancer applications (NIPT, transplant diagnostics, others)
- Various end users of the liquid biopsy market are hospitals, reference laboratories, academic & research institutes and others. The availability of advanced genetic testing equipment has led an increased volume of liquid biopsy test samples outsourced to reference laboratories globally
Liquid Biopsy Market by Regional Trends
By geography, the global liquid biopsy market is studied across the countries of key regions such as, North America, Europe, Asia Pacific and rest of the world. In 2019, North America held the largest revenue share mainly due to factors such as government support for quality healthcare, high purchasing power parity and availability of reimbursement. Furthermore, Asia Pacific is expected to witness lucrative growth over the forecast period owing to supportive government initiatives, pioneering presence in healthcare development and rapid adoption of the technological innovations. Additionally, economic developments in countries, such as India and China, are expected to help spur the market growth. Huge population base with low per capita income in the region led to high demand for affordable treatment options.
Liquid Biopsy Market Key Players
The leading liquid biopsy market players are are Adaptive Biotechnologies, Biocept, Inc., Cynvenio Biosystems, Inc., Foundation Medicine, Inc., Genomic Health, Inc., Guardant Health, Inc., Myriad Genetics, Inc., NeoGenomics Laboratories, Inc., OncoCyte Corporation, Personal Genome Diagnostics, Inc., QIAGEN, RainDance Technologies, Inc., Trovagene Inc., Veracyte, Inc, Inc. and Vermillion, Inc. among others. Many biotechnological companies have started their trials in China as clinical trial regulations are comparatively soft, thus, encouraging businesses to shift their base from America and Europe, where costlier trials are required for approval and reimbursement. The growing investments in research and development of healthcare industry have been encouraging the market players to offer effective solutions to gain a competitive edge in the liquid biopsy market.
The report analyses the global liquid biopsy market based on products, circulating biomarker, sample type, application, end user and geography. Based on products, the market is categorized into assay kits, instruments and services. The liquid biopsy instruments automate the isolation of CTC cells. The instrument automates flow cell priming, blood sample loading, target cell isolation, and immunofluorescent labeling of captured cells on the flow chip.Various circulating biomarkers of the liquid biopsy market are Cell-Free DNA (cfDNA), Circulating Tumor Cells (CTCs), Circulating Tumor DNA (ctDNA), Extracellular Vesicles (EVs) and Other circulating biomarkers include circulating RNA (ctRNA and cfRNA) and cell-free protein biomarkers. Since liquid biopsies can detect tumor-associated genetic alterations, they can be used to molecularly stratify tumors to guide the most appropriate targeted treatment for precision oncology.
The global market is studied for the key regions such as, North America, Europe, Asia Pacific and Rest of the World. North America comprises of U.S., Canada and Mexico. Whereas, Europe covers UK, France, Germany, Italy, Spain and Rest of Europe.
Why to buy this report:
- The report offers changing market dynamics in the Liquid biopsy market, presenting historical, current and projected market size in terms of value (USD Million)
- The research study provides an in-depth analysis of the industry value chain focusing on the peer and parent markets of Liquid biopsy
- It presents a comprehensive assessment of geographical regions exhibiting promising growth, potential and niche segments, and a neutral perspective on the Liquid biopsy market performance
- The report also offers strategic recommendations in key business segments based on the market estimations and competitive landscape, mapping the key common trends of Liquid biopsy market
